Perilymph Osmolality Modulates Cochlear Function
نویسندگان
چکیده
منابع مشابه
Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani.
Measurements of drug levels in the fluids of the inner ear are required to establish kinetic parameters and to determine the influence of specific local delivery protocols. For most substances, this requires cochlear fluids samples to be obtained for analysis. When auditory function is of primary interest, the drug level in the perilymph of scala tympani (ST) is most relevant, since drug in thi...
متن کاملContamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid.
Our understanding of the perilymph kinetics of drugs depends largely on data obtained by the analysis of perilymph samples. Although a number of studies have demonstrated qualitatively that perilymph samples may be contaminated by cerebrospinal fluid (CSF), and some investigations adopt specific methods to minimize CSF contamination of their samples, many other studies fail to consider the infl...
متن کاملComparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.
BACKGROUND AND PURPOSE 3D-FLAIR imaging 24 hours after intratympanic gadolinium injection (IT-method) or 4 hours after IV injection (IV-method) has been used to visualize the endolymphatic hydrops in Ménière disease. The purpose of this study was to compare the degree of perilymph enhancement with the 2 methods and the perilymph contrast-effect difference with the IV-method in both sides in pat...
متن کاملPerilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs
Patients undergoing cochlear implantation could benefit from a simultaneous application of drugs into the ear, helping preserve residual low-frequency hearing and afferent nerve fiber populations. One way to apply drugs is to incorporate a cannula into the implant, through which drug solution is driven. For such an approach, perilymph concentrations achieved and the distribution in the ear over...
متن کاملEffect of artificial endolymph injection into the cochlear duct on perilymph potassium.
OBJECTIVE To investigate the relationship between endolymphatic hydrops and perilymphatic potassium. METHODS 20 pigmented guinea pigs were used: 10 for scala vestibuli study and 10 for scala tympani study. Acute endolymphatic hydrops was produced by microinjection of an artificial endolymph into the scala media. Injections were performed in the second turn at rates up to 500 nl/min for a peri...
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ژورنال
عنوان ژورنال: The Laryngoscope
سال: 2008
ISSN: 0023-852X
DOI: 10.1097/mlg.0b013e3181788d72